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Vader didn't object to Alderaan being destroyed. I mean, technically it's on the guy who pulled the switch, not Tarkin, but Vader and Tarkin are also culpable. Ahsoka's eyes were yellow so it makes sense that Anakin was similarly possessed. I thought it made sense that only through the Unifying Force (Father) did the Dark Side flow, so by the Father being mortally wounded, the Son lost his immunity to weapons that aren't the dagger.
I thought it was symbolic of the fact that the dark side is self-destructive, insofar as that the Son's goal through the trilogy was to kill the Father, but as we learn at the end when the Father dies the Son loses his power, something he was ignorant of. Also liked how the Daughter died in the previous episode, reflecting the Jedi, and the Son died in this one, reflecting the Sith. Anakin balances Mortis by having everyone die, just as he balances the Force by having all the Jedi and all the Sith die.
I also like the idea espoused by Sam Witwer, as relayed by David Collins, about how in the prior episode the dagger of Mortis, while in the altar, is just the hilt, but upon grabbing it the blade materializes, similar to a lightsaber. Almost suggesting that the lightsabers are a technological analog to this more mystical weapon, a Jedi attempt to replicate it.