|I'll post a fiction and a non-fiction.
House Of Leaves by Mark Danielewski.
I think it's probably the best book of the 21st century. Like all great works of literature it's about how people see themselves and relate to other people. It's also about how storytelling is a defining characteristic of the human experience.
The plot is that a young man acquires and publishes a manuscript from his former neighbor that is an analysis of a movie.
It has three main storylines. The central narrative is the movie which is about a family that moves into a house that's a gateway to another dimension. The other two stories are told in footnotes by the author and the publisher.
It's up to the reader to decide how the stories fit together. Another feature of great literature is that it's not a passive listening experience, but an active and engaging process by the reader.
In the middle of the book is over 25 pages of bibliography and film listings. This is to illustrate three key points of the book: A book is a puzzle that you have to work at solving if you want it to give up it's secrets. A story is an intangible thing created in the imagination of the reader and not in the words on a page. I'll leave the third lesson up to you to find.
It also has different colored text, font, font size, writing direction including backwards writing to view in a mirror, coded messages, poems, diary entries and photographs.
Non-fiction: I'll post that later.
Ha! I was about to post on this as well.
My recommendation would have to be The White Plague by Frank Herbert. A story about a man who's wife and daughter are killed in an IRA bombing and in his grief deprives the rest of the world of the same by creating a virus that only kills women, attacking the female chromosomes. Its a great story, split between the scientist and the team working on a cure. It gets into a lot of messed up psychology, but its amazing.
Perfection is a lifelong pursuit requiring sacrifice. The only way to get it quicker is to sacrifice the most.